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JJ-450

Chemical Structure : JJ-450

CAS No.: 2772026-11-4

JJ-450 (JJ450)

Catalog No.: PC-49173Not For Human Use, Lab Use Only.

JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression.
    JJ-450 also inhibits ARv7 transcriptional activity and its target gene expression.

    Physicochemical Properties

    M.Wt 372.868
    Formula C21H22ClFN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (4-(5-chloro-2-methylphenyl)piperazin-1-yl)(2-(4-fluorophenyl)cyclopropyl)methanone

    References

    1. Yang Z, et al. Mol Cancer Ther. 2020 Jan;19(1):75-88.

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