| Cat. No. |
Product Name |
Information |
| PC-45422 |
GLPG-0492 R enantiomer
|
The R enantiomer of GLPG-0492, a non-steroidal selective androgen receptor modulator (SARM) for treatment for Duchenne muscular dystrophy (DMD). |
| PC-45932 |
Enzalutamide
AR antagonist
|
Enzalutamide (MDV3100) is a potent, selective and orally available androgen-receptor (AR) antagonist with IC50 of 36 nM. |
| PC-45113 |
ODM-201
AR antagonist
|
ODM-201 (BAY-1841788, Darolutamide) is a potent wt/mutant androgen receptor (AR) inhibitor with Ki of 11 nM. |
| PC-45421 |
GLPG-0492
|
A novel, orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM. |
| PC-22067 |
SC912
AR-V7 inhibitor
|
SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding. |
| PC-22037 |
Bicalutamide
AR inhibitor
|
Bicalutamide (ICI 176,334) is an orally active non-steroidal androgen receptor (AR) antagonist for treatment of prostate cancer. |
| PC-21883 |
(+)-JJ-74-138
Androgen Receptor inhibitor
|
(+)-JJ-74-138 is a non-competitive androgen receptor (AR) antagonist, directly interacts with AR with SPR KD of 4.29 uM, inhibits AR with mutations in the LBD or lacking ligand binding domain (LBD). |
| PC-21502 |
AR inhibitor 1ae
AR inhibitor
|
AR inhibitor 1ae is a small-molecule inhibitor of the androgen receptor activation domain (AR AD) with IC50 of 1.54 uM in androgen-induced PSA-luciferase assays, inhibits AR-V7 transcriptional activity with IC50 of 4.1 uM. |
| PC-21406 |
UT-155
AR inhibitor
|
UT-155 is a potent and selective AR degrader (SARD), binds to AR-LBD (Ki=267 nM), degrades and inhibits AR and AR splice variants (AR-SVs), including AR-V7. |
| PC-21405 |
UT-34
AR inhibitor
|
UT-34 is a potent, second-generation androgen receptor (AR) pan antagonist, degrades enzalutamide-sensitive and -resistant ARs and AR splice variants (AR-SVs). |
| PC-21404 |
UT-105
AR inhibitor
|
UT-105 is a small-molecule, irreversible, selective androgen receptor (AR) degrader (SARD) and irreversible inhibitor, binds to AR N-terminal domain (NTD) and inhibits both the AR and AR splice variants (AR-SVs). |
| PC-20797 |
M17-B15
AR inhibitor
|
M17-B15 is a potent, specific small molecule inhibitor of androgen receptor (AR) targeting the dimer interface pocket (DIP), inhibits AR transcriptional inhibition with IC50 of 0.03 uM. |
