Catalog No.: PC-61678Not For Human Use, Lab Use Only.
EPI-001 is a small molecule that blocks transactivation of the androgen Receptor (AR) NTD (IC50=6 uM) and specificly inhibits AR without attenuating transcriptional activities of related steroid receptors.
EPI-001 (EPI 001) is a small molecule that blocks transactivation of the androgen receptor (AR) NTD (IC50=6 uM) and specificly inhibits AR without attenuating transcriptional activities of related steroid receptors.
EPI-001 targets the transactivation unit 5 of AR and interacts with AF-1 in the NTD to prevent protein-protein interactions.
EPI-001 inhibits endogenous expression of androgen-regulated genes, inhibits both androgen-dependent and androgen-independent (OCM-induced) proliferation of LNCaP cells.
EPI-001 reduces the growth of CRPC xenografts; also is a selective PPAR-gamma modulator.
