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Chemical Structure : BAY 1024767
Catalog No.: PC-35003Not For Human Use, Lab Use Only.
BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).
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BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).
BAY 1024767 inhibits mutants L701H, E709Y, V715M, W741C, H874Y (IC50=31 nM), F876L, T877A, M895T and M895V (IC50=11 nM).
BAY 1024767 promotes nuclear localization of AR wild-type and mutants in the absence of R1881 in COS-7 cells.
BAY 1024767 demonstrates KuCaP-1 prostate cancer model which bears the W741C bicalutamide resistance mutation and in the syngeneic prostate cancer rat model Dunning R3327-G.
| M.Wt | 492.517 | |
| Formula | C23H23F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sugawara T, et al. Oncotarget. 2016 Feb 2;7(5):6015-28.
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