Catalog No.: PC-35003Not For Human Use, Lab Use Only.
BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).
BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).
BAY 1024767 inhibits mutants L701H, E709Y, V715M, W741C, H874Y (IC50=31 nM), F876L, T877A, M895T and M895V (IC50=11 nM).
BAY 1024767 promotes nuclear localization of AR wild-type and mutants in the absence of R1881 in COS-7 cells.
BAY 1024767 demonstrates KuCaP-1 prostate cancer model which bears the W741C bicalutamide resistance mutation and in the syngeneic prostate cancer rat model Dunning R3327-G.
