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LGD-3303

Chemical Structure : LGD-3303

CAS No.: 917891-35-1

LGD-3303 (LGD3303)

Catalog No.: PC-61861Not For Human Use, Lab Use Only.

LGD-3303 is an orally available, brain-penetrant nonsteroidal selective androgen receptor modulator (SARM) that that shows little or no cross-reactivity with related nuclear receptors.

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Biological Activity

LGD-3303 is an orally available, brain-penetrant nonsteroidal selective androgen receptor modulator (SARM) that that shows little or no cross-reactivity with related nuclear receptors.
LGD-3303 has potent activity on levator ani muscle but is a partial agonist on the preputial gland and ventral prostate in a castrated rat model of androgen deficiency。
LGD-3303 enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats.

Physicochemical Properties

M.Wt 342.743
Formula C16H14ClF3N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo(3,2-F)quinolin-7(6H)-one

References

1. Vajda EG, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):663-70.

2. Vajda EG, et al. J Bone Miner Res. 2009 Feb;24(2):231-40.

3. Kudwa AE, et al. Endocrinology. 2010 Jun;151(6):2659-68.

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