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LY2452473

Chemical Structure : LY2452473

CAS No.: 1029692-15-6

LY2452473 (TT 701;OPK 88004)

Catalog No.: PC-61999Not For Human Use, Lab Use Only.

LY2452473 (TT 701.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LY2452473 (TT 701;OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism; has the potential advantage of eliciting androgen receptor specificity and tissue selectivity to produce the beneficial effects of testosterone on bone, muscle, and improvements in erectile function over a PDE5i alone, with minimal steroid-related adverse effects.

Prostate Cancer

Phase 2 Clinical

Physicochemical Properties

M.Wt 374.444
Formula C22H22N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

References

1. Yi P, et al. Drug Metab Dispos. 2012 Dec;40(12):2354-64.

2. Noey EL, et al. J Org Chem. 2017 Jun 2;82(11):5904-5909.

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