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IMTPPE

Chemical Structure : IMTPPE

CAS No.: 851688-13-6

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IMTPPE (SID 3712502)

Catalog No.: PC-35866Not For Human Use, Lab Use Only.

IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.
    IMTPPE inhibited proliferation of AR-positive, but not AR-negative, prostate cancer cells in culture.
    IMTPPE inhibited the transcriptional activity of a mutant AR lacking the ligand-binding domain (LBD).
    IMTPPE inhibited the growth of 22Rv1 xenograft tumor, a model for enzalutamide-resistant prostate cancer.

    Physicochemical Properties

    M.Wt 373.52
    Formula C20H27N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)-1-(4-(2,3-dimethylphenyl)piperazin-1-yl)ethan-1-one

    References

    1. Masoodi KZ, et al. Endocrinology. 2017 Oct 1;158(10):3152-3161.

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