ADGRD1 agonist GL64 | GPR133 agonist | Probechem Biochemicals

Chemical Structure : ADGRD1 agonist GL64

ADGRD1 agonist GL64 (GPR133 agonist GL64)

Catalog No.: PC-24994Not For Human Use, Lab Use Only.

ADGRD1 agonist GL64 is a selective agonist of ADGRD1/GPR133 with EC50 of 3.98 uM in CRE-luciferase assays in ADGRD1-overexpressing HEK293T cells.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

ADGRD1 agonist GL64 is a selective agonist of ADGRD1/GPR133 with EC50 of 3.98 uM in CRE-luciferase assays in ADGRD1-overexpressing HEK293T cells.
GL64 shows no effect in HEK293T cells overexpressing adhesion GPCRs, such as ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4.
GL64 also does not activate nonadhesion GPCRs, including GPR68, NPFFR1, GPR183, and GPRC5B.
GL64 (10 μM) inhibits the differentiation of male WT BMMs into mature osteoclasts but had no effect on Adgrd1−/− cells, down-regulates the expression levels of osteoclastogenesis-related genes, including Dc-stamp, Acp5, and Nfatc1, during male mouse osteoclast maturation.
GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway.
GL64 (30 mg/kg, i.p.) rescues ovariectomy-induced bone loss and osteoclast hyperactivity in OVX-induced osteoporosis mice.

Physicochemical Properties

M.Wt	509.81
Formula	C27H19Cl3N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-2-(3-((2,4-dichlorobenzyl) oxy)phenyl)-2,3-dihydroquinazo lin-4(1H)-one

References

1. He L, et al. Sci Adv. 2025 Jul 11;11(28):eads3829.

ADGRD1 agonist GL64 (GPR133 agonist GL64)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.