AP503 (AP-970/43482503) | GPR133 agonist

Chemical Structure : AP503

CAS No.: 767299-99-0

AP503 (AP-503, AP-970/43482503)

Catalog No.: PC-24037Not For Human Use, Lab Use Only.

AP503 (AP-970/43482503) is a potent, specific small molecule agonist of androgen membrane receptor GPR133 (ADGRD1) with EC50 of 1.21 nM.

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5 mg	$358	In stock
10 mg	$548	In stock
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Biological Activity

AP503 (AP-970/43482503) is a potent, specific small molecule agonist of androgen membrane receptor GPR133 (ADGRD1) with EC50 of 1.21 nM.

AP503 activates the Gs but not the G12 or Gi pathway of GPR133.

AP503 shows no detectable activity for AR or other aGPCR members.

AP503 enhances muscle strength without eliciting androgenic adverse effects, significantly promotes the tetanic contraction forces of isolated EDLs through PKA-mediated signaling.

GPR133 represents an androgen membrane receptor that contributes to normal androgen physiology and has important therapeutic potentials.

Physicochemical Properties

M.Wt	425.53
Formula	C24H31N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-(2-(2,4-dimethylphenoxy)acetamido)-4-(4-ethylpiperazin-1-yl)benzoate

References

1. Yang Z, et al. Cell. 2025 Jan 23:S0092-8674(25)00035-2.

AP503 (AP-503, AP-970/43482503)

Biological Activity

Physicochemical Properties

References

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