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SC912

Chemical Structure : SC912

CAS No.:

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SC912 (SC-912)

Catalog No.: PC-22067Not For Human Use, Lab Use Only.

SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding.
SC912 suppresses proliferation, induces cell-cycle arrest, and apoptosis in AR-V7 positive CRPC cells.
SC912 attenuates tumor growth and antagonized intratumoral AR signaling in AR-V7 expressing CRPC xenografts.

Physicochemical Properties

M.Wt 493.27
Formula C22H13Cl2F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,5-dichloro-N-(2-(3-(3-cyanophenyl)ureido)-5-(trifluoromethyl)phenyl)benzamide

References

1. Qianhui Yi, et al. Oncogene. 2024 Mar 26. doi: 10.1038/s41388-024-02944-2.

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