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Chemical Structure : SC912
Catalog No.: PC-22067Not For Human Use, Lab Use Only.
SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding.
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SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding.
SC912 suppresses proliferation, induces cell-cycle arrest, and apoptosis in AR-V7 positive CRPC cells.
SC912 attenuates tumor growth and antagonized intratumoral AR signaling in AR-V7 expressing CRPC xenografts.
| M.Wt | 493.27 | |
| Formula | C22H13Cl2F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qianhui Yi, et al. Oncogene. 2024 Mar 26. doi: 10.1038/s41388-024-02944-2.
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