Catalog No.: PC-22067Not For Human Use, Lab Use Only.
SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding.
SC912 is a small molecule inhibitor of androgen receptor AR-V7, binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD), disruptes AR-V7 transcriptional activity, impairs AR-V7 nuclear localization and DNA binding.
SC912 suppresses proliferation, induces cell-cycle arrest, and apoptosis in AR-V7 positive CRPC cells.
SC912 attenuates tumor growth and antagonized intratumoral AR signaling in AR-V7 expressing CRPC xenografts.
