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Chemical Structure : UT-155
CAS No.: 2031161-35-8
Catalog No.: PC-21406Not For Human Use, Lab Use Only.
UT-155 is a potent and selective AR degrader (SARD), binds to AR-LBD (Ki=267 nM), degrades and inhibits AR and AR splice variants (AR-SVs), including AR-V7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote |
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UT-155 is a potent and selective AR degrader (SARD), binds to AR-LBD (Ki=267 nM), degrades and inhibits AR and AR splice variants (AR-SVs), including AR-V7.
UT-155 potently inhibits the R1881-induced wildtype AR transactivation with 6-10-fold higher potency than enzalutamide.
UT-155, but not enzalutamide, inhibits the expression of PSA in LNCaP-EnzR (F876L-AR).
UT-155 reduces AR expression and promotes degradation of the AR potentially through proteasome pathway.
UT-155 promotes degradation of splice-variants of AR in in 22RV1 cells, inhibits AR-target gene expression.
UT-155 binds to AR Activation Function Domain 1 (AF-1) between amino acids 244 and 360 with Kd of 1.32 uM, but not to the LBD.
UT-155 inhibits AR- and AR-SV-dependent PCa cell proliferation. UT-155 inhibits growth of AR-SV-dependent prostate cancer xenografts.
| M.Wt | 405.35 | |
| Formula | C20H15F4N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(αS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-1H-indole-1-propanamide |
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1. Ponnusamy S, et al. Cancer Res. 2017 Nov 15;77(22):6282-6298.
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