MUS81 inhibitor 24

Chemical Structure : MUS81 inhibitor 24

Catalog No.: PC-22697Not For Human Use, Lab Use Only.

MUS81 inhibitor 24 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.27 uM and SPR Kd of 1.1 uM (MUS81-EME1).

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Biological Activity

MUS81 inhibitor 24 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.27 uM and SPR Kd of 1.1 uM (MUS81-EME1).
The Mus81 endonuclease resolves recombination intermediates and mediates cellular responses to exogenous replicative stress.

Physicochemical Properties

M.Wt	444.45
Formula	C24H20N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4'-(2-cyanopiperazine-1-carbonyl)-[1,1'-biphenyl]-4-yl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxylic acid

References

1. Collie GW, et al. ACS Med Chem Lett. 2024 Jun 7;15(7):1151-1158.

2. Haiqing Fu, et al. Nat Commun. 2015 Apr 16:6:6746.

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