ATX-101 | PCNA inhibitor | Probechem Biochemicals

Chemical Structure : ATX-101

ATX-101 (ATX101)

Catalog No.: PC-24066Not For Human Use, Lab Use Only.

ATX-101 is an APIM-containing cell-penetrating peptide targeting PCNA, impairs the APIM-PCNA interaction.

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Biological Activity

ATX-101 is an APIM-containing cell-penetrating peptide targeting PCNA, impairs the APIM-PCNA interaction.
ATX-101 inhibits cell growth of cancer cell lines, increases the sensitivity of MM cell lines against other chemotherapeutics such as thalidomide, doxorubicin, vorinostat, azacitidine, and various kinase inhibitors.
ATX-101 induces apoptosis in the MM cell line JJN-3.
ATX-101 induces caspase cleavage by inhibiting PCNA-procaspase interactions. ATX-101 induces apoptosis preferentially in cancer cell lines.
ATX-101 induces apoptosis in primary MM cells and increases the efficacy of melphalan in vivo.

Physicochemical Properties

M.Wt	3675.55
Formula	C158H285N71O29S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sequence: Ac-Met-Asp-Arg-Trp-Leu-Val-Lys-Trp-Lys-Lys-Lys-Arg-Lys-Ile-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

References

1. Rebekka Müller, et al. PLoS One. 2013 Jul 31;8(7):e70430.

ATX-101 (ATX101)

Biological Activity

Physicochemical Properties

References

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