MTH1 inhibitor AZ19

Chemical Structure : MTH1 inhibitor AZ19

Catalog No.: PC-20533Not For Human Use, Lab Use Only.

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

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Biological Activity

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

Physicochemical Properties

M.Wt	389.81
Formula	C19H17ClFN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=C(NC2=CC=C(Cl)C=C2F)C3=CC(OC)=C(OC)C=C3N=C1)NC

References

1. Jason G Kettle, et al. J Med Chem. 2016 Mar 24;59(6):2346-61.

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