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MTH1 inhibitor AZ19

Chemical Structure : MTH1 inhibitor AZ19

CAS No.: 1870031-98-3

MTH1 inhibitor AZ19

Catalog No.: PC-20533Not For Human Use, Lab Use Only.

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MTH1 inhibitor AZ19 is a highly potent MTH1 inhibitor with IC50 of 0.9 nM and Kd of 0.5 nM, displays EC50 of 7 nM in whole cell thermal stability assay in K562 cells.

Physicochemical Properties

M.Wt 389.81
Formula C19H17ClFN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(C1=C(NC2=CC=C(Cl)C=C2F)C3=CC(OC)=C(OC)C=C3N=C1)NC

References

1. Jason G Kettle, et al. J Med Chem. 2016 Mar 24;59(6):2346-61.

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