| Cat. No. |
Product Name |
Information |
| PC-45105 |
TH-287 hydrochloride
MTH1 inhibitor
|
TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-45104 |
TH-287
MTH1 inhibitor
|
TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-23728 |
PFM03
MRE11 inhibitor
|
PFM03 is a specific MRE11 endonuclease inhibitor, affects DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ). |
| PC-23727 |
MU147
MRE11 inhibitor
|
MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination. |
| PC-23726 |
MU1409
MRE11 inhibitor
|
MU1409 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 12.1 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination. |
| PC-22774 |
HDGFRP2 PWWP domain inhibitor BBP
HDGFRP2 PWWP inhibitor
|
BBP is a small molecule inhibitor of the hepatoma-derived growth factor-related protein 2 (HDGFRP2) PWWP domain, dually targets both HDGFRP2 and PSIP1 PWWP domains, engage with the aromatic cage of the HDGFRP2 PWWP domain. |
| PC-22697 |
MUS81 inhibitor 24
MUS81 inhibitor
|
MUS81 inhibitor 24 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.27 uM and SPR Kd of 1.1 uM (MUS81-EME1). |
| PC-22696 |
MUS81 inhibitor 23
MUS81 inhibitor
|
MUS81 inhibitor 23 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.32 uM and SPR Kd of 0.67 uM (MUS81-EME1). |
| PC-22445 |
SNM1A inhibitor 19
SNM1A inhibitor
|
SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage. |
| PC-22110 |
GSK_WRN4
WRN helicase inhibitor
|
GSK_WRN4 (WRNi, GSK-WRN4) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 7.6, covalently targets WRN Cys727 residue. |
| PC-22109 |
GSK_WRN3
WRN helicase inhibitor
|
GSK_WRN3 (WRNi, GSK-WRN3) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 8.6, covalently targets WRN Cys727 residue. |
| PC-22108 |
GSK_WRN2
WRN helicase inhibitor
|
GSK_WRN2 is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 6.5, covalently targets WRN Cys727 residue. |
