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NSC 19630

Chemical Structure : NSC 19630

CAS No.: 72835-26-8

NSC 19630 (MIRA-1)

Catalog No.: PC-61921Not For Human Use, Lab Use Only.

NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.

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Biological Activity

NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
NSC 19630 (MIRA-1) shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB).
NSC 19630 (MIRA-1) dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated γ-H2AX and PCNA foci in human cells.
NSC 19630 (MIRA-1) delays S-phase progression and induces DNA damage;.
NSC 19630 (MIRA-1) is a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.

Physicochemical Properties

M.Wt 183.2
Formula C8H9NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione

References

1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30.

2. Saha MN, et al. Br J Cancer. 2014 Apr 29;110(9):2224-31.

3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26;280(34):30384-91.

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