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Chemical Structure : TH-588
CAS No.: 1609960-31-7
Catalog No.: PC-43226Not For Human Use, Lab Use Only.
TH-588 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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TH-588 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM.
TH-588 shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity.
TH-588 causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
| M.Wt | 295.1672 | |
| Formula | C13H12Cl2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 16 mg/mL |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)- |
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1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.
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