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Rev1-IN-5

Chemical Structure : Rev1-IN-5

CAS No.: 908510-73-6

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Rev1-IN-5

Catalog No.: PC-61900Not For Human Use, Lab Use Only.

Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM.
    Rev1-IN-5 binds to Rev1-CT at the RIR interface.
    Rev1-IN-5 inhibits mutagenic Rev1/Polζ-dependent translesion synthesis (TLS) in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells.

    Physicochemical Properties

    M.Wt 403.541
    Formula C21H29N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-acetyl-N-(3-(cyclopropylcarbamoyl)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)piperidine-4-carboxamide

    References

    1. Sail V, et al. ACS Chem Biol. 2017 Jul 21;12(7):1903-1912.

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