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Chemical Structure : Rev1-IN-5
Catalog No.: PC-61900Not For Human Use, Lab Use Only.
Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM.
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Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM.
Rev1-IN-5 binds to Rev1-CT at the RIR interface.
Rev1-IN-5 inhibits mutagenic Rev1/Polζ-dependent translesion synthesis (TLS) in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells.
| M.Wt | 403.541 | |
| Formula | C21H29N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sail V, et al. ACS Chem Biol. 2017 Jul 21;12(7):1903-1912.
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