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PFM39

Chemical Structure : PFM39

CAS No.: 1310744-67-2

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PFM39 (SML1839)

Catalog No.: PC-61925Not For Human Use, Lab Use Only.

PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.

Physicochemical Properties

M.Wt 219.262
Formula C10H9N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone

References

1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.

2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

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