Catalog No.: PC-61924Not For Human Use, Lab Use Only.
6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
6-Hydroxy-DOPA inhibits RAD52 foci formation in murine hematopoietic cells deficient in BRCA1, and kills BRCA-deficient cancer cells.
6-Hydroxy-DOPA also inhibits human apurinic/apyrimidinic endonuclease APE1 and enhances the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.
Physicochemical Properties
M.Wt
213.189
Formula
C9H11NO5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Alanine, 3-(2,4,5-trihydroxyphenyl)- (7CI,8CI)
References
1. Chandramouly G, et al. Chem Biol. 2015 Nov 19;22(11):1491-1504.
2. Simeonov A, et al. PLoS One. 2009 Jun 1;4(6):e5740.
