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PFM01

Chemical Structure : PFM01

CAS No.: 1558598-41-6

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PFM01 (SML1735)

Catalog No.: PC-61926Not For Human Use, Lab Use Only.

PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.
PFM01 blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.

Physicochemical Properties

M.Wt 293.399
Formula C14H15NO2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone

References

1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.

2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

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