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NSC 617145

Chemical Structure : NSC 617145

CAS No.: 203115-63-3

NSC 617145 (NSC617145)

Catalog No.: PC-61920Not For Human Use, Lab Use Only.

NSC 617145 is a novel small-molecule, selective inhibitor of WRN helicase with IC50 of 230 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC 617145 is a novel small-molecule, selective inhibitor of WRN helicase with IC50 of 230 nM.
NSC 617145 shows no significant inhibition on BLM, FANCJ, ChlR1, RecQ, and UvrD.
NSC 617145 acts synergistically with very low concentrations of mitomycin C to inhibit proliferation in a WRN-dependent manner and induce DSB and chromosomal abnormalities in FA-D2(-/-) cells.

Physicochemical Properties

M.Wt 400.04
Formula C13H10Cl4N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione

References

1. Aggarwal M, et al. Cancer Res. 2013 Sep 1;73(17):5497-507.

2. Aggarwal M, et al. Cell Cycle. 2013 Oct 15;12(20):3329-35.

3. Moles R, et al. J Hematol Oncol. 2016 Nov 9;9(1):121.

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