| Cat. No. |
Product Name |
Information |
| PC-60677 |
AR03
APE1 inhibitor
|
AR03 (BMH-23, AR03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM. |
| PC-60634 |
Erenapurstat
APE1/Ref-1 inhibitor
|
Erenapurstat (E3330, APX3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1)/redox factor-1 (Ref-1) redox function with IC50 of 50 uM, but not APE1 DNA repair activity. |
| PC-60633 |
APX2009
Ref-1/APE1 inhibitor
|
APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition. |
| PC-60602 |
Lucanthone
APE1 inhibitor
|
Lucanthone is an ionizing radiation enhancer and apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor with IC50 of 5 uM for inhibition of APE1 incision of depurinated plasmid DNA, also may act as an inhibitor of protein palmitoyl thioesterase 1 (PPT1). |
| PC-45763 |
(Z)-Mirin
MRE11 inhibitor
|
(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity. |
| PC-42079 |
HUHS-015
PCA-1/ALKBH3 inhibitor
|
HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM. |
| PC-43227 |
TH588 hydrochloride
MTH1 inhibitor
|
TH588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-43226 |
TH588
MTH1 inhibitor
|
TH588 (TH-588) is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-45105 |
TH-287 hydrochloride
MTH1 inhibitor
|
TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-45104 |
TH287
MTH1 inhibitor
|
TH287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-27895 |
(S)-Crizotinib
MTH1 inhibitor
|
(S)-Crizotinib is a potent inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase MTH1 (NUDT1) with IC50 of 72 nM and ITC KD of 47 nM. |
| PC-27894 |
MI-743
MTH1 inhibitor
|
MI-743 is a potent, specific inhibitor of human mutT homolog 1 (MTH1, Nudix hydrolase 1, NUDT1) with IC50 of 91.44 nM. |
