| Cat. No. |
Product Name |
Information |
| PC-42079 |
HUHS-015
PCA-1/ALKBH3 inhibitor
|
HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM. |
| PC-43227 |
TH588 hydrochloride
MTH1 inhibitor
|
TH588 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-43226 |
TH588
MTH1 inhibitor
|
TH588 (TH-588) is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-45105 |
TH-287 hydrochloride
MTH1 inhibitor
|
TH-287 hydrochloride is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-45104 |
TH287
MTH1 inhibitor
|
TH287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
| PC-27895 |
(S)-Crizotinib
MTH1 inhibitor
|
(S)-Crizotinib is a potent inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase MTH1 (NUDT1) with IC50 of 72 nM and ITC KD of 47 nM. |
| PC-27894 |
MI-743
MTH1 inhibitor
|
MI-743 is a potent, specific inhibitor of human mutT homolog 1 (MTH1, Nudix hydrolase 1, NUDT1) with IC50 of 91.44 nM. |
| PC-27771 |
CHD4 inhibitor CH41
CHD4 inhibitor
|
CHD4 inhibitor CH41 is a potent small-molecule inhibitor of chromodomain helicase DNA-binding protein 4 (CHD4) with EC50 of 761 nM, recapitulates the effects of genetic CHD4 ablation on Treg function. |
| PC-27648 |
RECQL5-IN-1
RECQL5 inhibitor
|
RECQL5-IN-1 is a specific small molecule inhibitor of DNA helicase RECQL5, inhibits RECQL5-helicase activity and stabilizes RECQL5-RAD51 physical interaction, preferentially kills RECQL5-expressing breast cancers but not RECQL5 knockout. |
| PC-27643 |
WRN helicase WC-2
WRN inhibitor
|
WRN helicase WC-2 is a potent, covalent and orally bioavailable WRN helicase inhibitor, exhibits cellular potency in the nanomolar range in both p21 induction and HCT116 CTG viability assays. |
| PC-27257 |
MWAC-1657
TREX1 inhibitor
|
MWAC-1657 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 154 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2. |
| PC-27256 |
MWAC-1655
TREX1 inhibitor
|
MWAC-1655 is a highly potent, selective three-prime Repair EXonuclease 1 (TREX1) inhibitor with IC50 of 64.2 nM (hTREX1), >100-fold selectivity toward hTREX1 over hTREX2. |
