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Chemical Structure : AR03
Catalog No.: PC-60677Not For Human Use, Lab Use Only.
AR03 (BMH-23, AR03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM.
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AR03 (BMH-23, AR03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM.
AR03 shows 8-fold less effectivity in inhibiting endonuclease IV, and no effect on the redox activity of Ape1 or the ability of c-Jun/c-Fos to bind DNA.
AR03 has low affinity for double-stranded DNA and weakly inhibits the Escherichia coli endonuclease IV, requiring a 20-fold higher concentration than for inhibition of Ape1.
AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.
| M.Wt | 237.306 | |
| Formula | C15H15N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bapat A, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98.
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