| Cat. No. |
Product Name |
Information |
| PC-28556 |
EXO1 inhibitor compound 20
EXO1 inhibitor
|
EXO1 inhibitor compound 20 is a highly potent and selective exonuclease EXO1 inhibitor. |
| PC-27895 |
(S)-Crizotinib
MTH1 inhibitor
|
(S)-Crizotinib is a potent inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase MTH1 (NUDT1) with IC50 of 72 nM and ITC KD of 47 nM. |
| PC-27894 |
MI-743
MTH1 inhibitor
|
MI-743 is a potent, specific inhibitor of human mutT homolog 1 (MTH1, Nudix hydrolase 1, NUDT1) with IC50 of 91.44 nM. |
| PC-27771 |
CHD4 inhibitor CH41
CHD4 inhibitor
|
CHD4 inhibitor CH41 is a potent small-molecule inhibitor of chromodomain helicase DNA-binding protein 4 (CHD4) with EC50 of 761 nM, recapitulates the effects of genetic CHD4 ablation on Treg function. |
| PC-27648 |
RECQL5-IN-1
RECQL5 inhibitor
|
RECQL5-IN-1 is a specific small molecule inhibitor of DNA helicase RECQL5, inhibits RECQL5-helicase activity and stabilizes RECQL5-RAD51 physical interaction, preferentially kills RECQL5-expressing breast cancers but not RECQL5 knockout. |
| PC-27643 |
WRN helicase WC-2
WRN inhibitor
|
WRN helicase WC-2 is a potent, covalent and orally bioavailable WRN helicase inhibitor, exhibits cellular potency in the nanomolar range in both p21 induction and HCT116 CTG viability assays. |
| PC-26990 |
DHX33 inhibitor BCD38
DHX33 inhibitor
|
BCD38 is a small molecule inhibitor of RNA helicase DHX33, suppresses the helicase activity of DHX33 in vitro, induces similar effects as DHX33 knockdown. |
| PC-26960 |
TREX1-IN-4
TREX1 inhibitor
|
TREX1-IN-4 (Compound 96) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM. |
| PC-26950 |
NCGC00029283
WRN inhibitor
|
NCGC00029283 is a specific small molecule inhibitor of Werner Syndrome helicase-nuclease (WRN) with IC50 of 2.3 uM, 12.5 uM and 3.4 uM for WRN, BLM and FANCJ. |
| PC-26081 |
MU876
MUS81 inhibitor
|
MU876 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.52 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-26080 |
MU262
MUS81 inhibitor
|
MU262 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.87 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-25461 |
WRN degrader 14c
WRN degrader
|
WRN degrader 14c is a potent, selective degrader of Werner syndrome helicase (WRN) with DC50 of 1.7 uM in MSI-H HCT116 cells, covalently conjugates to C727 within the WRN helicase domain, forming an adamantane-tagged adduct that initiates sustained proteasomal degradation. |
