| Cat. No. |
Product Name |
Information |
| PC-26990 |
DHX33 inhibitor BCD38
DHX33 inhibitor
|
BCD38 is a small molecule inhibitor of RNA helicase DHX33, suppresses the helicase activity of DHX33 in vitro, induces similar effects as DHX33 knockdown. |
| PC-26961 |
NSC37215
TREX1 inhibitor
|
NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively. |
| PC-26960 |
TREX1-IN-4
TREX1 inhibitor
|
TREX1-IN-4 (Compound 96) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM. |
| PC-26959 |
TREX1-IN-3
TREX1 inhibitor
|
TREX1-IN-3 (Compound 95) is a potent dual inhibitor of DNA nucleases TREX1 and TREX2 with IC50 of <0.1 μM and < 1 μM, and has EC50 for HCT116 cells of < 1 μM. |
| PC-26950 |
NCGC00029283
WRN inhibitor
|
NCGC00029283 is a specific small molecule inhibitor of Werner Syndrome helicase-nuclease (WRN) with IC50 of 2.3 uM, 12.5 uM and 3.4 uM for WRN, BLM and FANCJ. |
| PC-26135 |
ART5537
EXO1 inhibitor
|
ART5537 (ART-5537) is highly potent and selective inhibitor of Exonuclease 1 (EXO1) with IC50 of 3.4 nM, inhibits homologous recombination (HR) with EC50 of 7.2 nM in HR reporter assays. |
| PC-26081 |
MU876
MUS81 inhibitor
|
MU876 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.52 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-26080 |
MU262
MUS81 inhibitor
|
MU262 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.87 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells. |
| PC-25461 |
WRN degrader 14c
WRN degrader
|
WRN degrader 14c is a potent, selective degrader of Werner syndrome helicase (WRN) with DC50 of 1.7 uM in MSI-H HCT116 cells, covalently conjugates to C727 within the WRN helicase domain, forming an adamantane-tagged adduct that initiates sustained proteasomal degradation. |
| PC-24739 |
WRN inhibitor 40
WRN inhibitor
|
WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727. |
| PC-24066 |
ATX-101
PCNA inhibitor
|
ATX-101 is an APIM-containing cell-penetrating peptide targeting PCNA, impairs the APIM-PCNA interaction. |
| PC-23728 |
PFM03
MRE11 inhibitor
|
PFM03 is a specific MRE11 endonuclease inhibitor, affects DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ). |
