WRN helicase WC-2

Chemical Structure : WRN helicase WC-2

Catalog No.: PC-27643Not For Human Use, Lab Use Only.

WRN helicase WC-2 is a potent, covalent and orally bioavailable WRN helicase inhibitor, exhibits cellular potency in the nanomolar range in both p21 induction and HCT116 CTG viability assays.

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Biological Activity

WRN helicase WC-2 is a potent, covalent and orally bioavailable WRN helicase inhibitor, exhibits cellular potency in the nanomolar range in both p21 induction and HCT116 CTG viability assays.

Physicochemical Properties

M.Wt	454.46
Formula	C21H21F3N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-N-(1-cyclopropyl-3-fluoro-3-(methylsulfonyl)allyl)-5-(1,1-difluoroethyl)-6-phenoxypicolinamide

References

1. Toure M, et al. J Med Chem. 2026 Aug 13;69(15):18162-18181.

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WRN helicase WC-2

Biological Activity

Physicochemical Properties

References

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