Chemical Structure : MU876
CAS No.:
1208829-24-6
MU876
(MU-876)
Catalog No.: PC-26081Not For Human Use, Lab Use Only.
MU876 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.52 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MU876 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.52 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells.
MU876 has no negative effect on NHEJ, does not broadly suppress DNA repair but impair only HR/BIR pathways.
MU876 decreases BIR to the same extent as the siRNA-mediated depletion of MUS81, with an IC50 of 0.24 uM, also significantly reduces the efficiency of HR repair with IC50 of 0.5-1 uM.
MU876 may block the binding by targeting the protein-DNA interface, inhibits the nuclease MUS81 via interfering with DNA binding.
MU876 significantly increases micronuclei formation in U2OS cells, similarly to the effect of MUS81 depletion.
MU876 induces persistent DNA damage leading to reduced cell survival, synergizes with cisplatin to reduce cancer cell viability.
Physicochemical Properties
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M.Wt
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438.45
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Formula
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C24H18N6O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(1-(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-3-phenyl-1H-pyrazol-5-yl)-5-phenylisoxazole-3-carboxamide
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References
1. Prochazkova J, et al. J Med Chem. 2026 Feb 25. doi: 10.1021/acs.jmedchem.5c02096.
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