Chemical Structure : RECQL5-IN-1
CAS No.:
2718170-45-5
RECQL5-IN-1
Catalog No.: PC-27648Not For Human Use, Lab Use Only.
RECQL5-IN-1 is a specific small molecule inhibitor of DNA helicase RECQL5, inhibits RECQL5-helicase activity and stabilizes RECQL5-RAD51 physical interaction, preferentially kills RECQL5-expressing breast cancers but not RECQL5 knockout.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RECQL5-IN-1 is a specific small molecule inhibitor of DNA helicase RECQL5, inhibits RECQL5-helicase activity and stabilizes RECQL5-RAD51 physical interaction, preferentially kills RECQL5-expressing breast cancers but not RECQL5 knockout.
RECQL5-IN-1 treatment led to the efficient sensitization of cisplatin-resistant breast cancers but not normal mammary epithelial cells.
RECQL5-IN-1 is orally effective in reducing the growth of RECQL5-expressing breast tumors (human xenograft) in NUDE-mice with no appreciable toxicity to the vital organs.
Physicochemical Properties
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M.Wt
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552.50
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Formula
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C25H18F6N4O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-((5-(benzylthio)-1,3,4-oxadiazol-2-yl)(phenyl)methyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea
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References
1. Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544.
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