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NCGC00029283

Chemical Structure : NCGC00029283

CAS No.: 714240-31-0

NCGC00029283

Catalog No.: PC-26950Not For Human Use, Lab Use Only.

NCGC00029283 is a specific small molecule inhibitor of Werner Syndrome helicase-nuclease (WRN) with IC50 of 2.3 uM, 12.5 uM and 3.4 uM for WRN, BLM and FANCJ.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NCGC00029283 is a specific small molecule inhibitor of Werner Syndrome helicase-nuclease (WRN) with IC50 of 2.3 uM, 12.5 uM and 3.4 uM for WRN, BLM and FANCJ.

Physicochemical Properties

M.Wt 337.31
Formula C18H12FN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one

References

1. Joshua A Sommers, et al. PLoS One. 2019 Jan 9;14(1):e0210525.

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