SNM1A inhibitor 19

Chemical Structure : SNM1A inhibitor 19

Catalog No.: PC-22445Not For Human Use, Lab Use Only.

SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage.

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Biological Activity

SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage.

Physicochemical Properties

M.Wt	361.79
Formula	C16H16ClN5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((6-chloro-2-((furan-2-ylmethyl)amino)quinazolin-4-yl)amino)-N-hydroxypropanamide

References

1. Marcin Bielinski, et al. Chem Sci. 2024 Apr 30;15(21):8227-8241.

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