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MU147

Chemical Structure : MU147

CAS No.: 2379405-61-3

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MU147 (MU-147)

Catalog No.: PC-23727Not For Human Use, Lab Use Only.

MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MU147 is a specific small molecule inhibitor of MRE11 nuclease with IC50 of 25.3 uM, inhibits MRE11-RAD50-NBS1 (MRN)-dependent homologous recombination.
MU147 inhibits MRE11 nuclease more specifically and effectively than mirin.
MU147 shows good selectivity against MUS81 and EXO1 (IC50>200 uM), but not FEN1(IC50=82.7 uM) in in vitro nuclease activity assays.
MU147 is significantly more effective at inhibiting exonuclease activity of MRE11 compared to mirin analog PFM01 in in vitro gel-based assays.
MU147 blocks MRE11 nuclease and affect DNA repair in cells.

Physicochemical Properties

M.Wt 363.39
Formula C19H13N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylthiazol-2-yl)acrylamide

References

1. Nikulenkov F, et al. Eur J Med Chem. 2025 Jan 1;285:117226.

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