NUDT5/NUDT14 inhibitor 9

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Chemical Structure : NUDT5/NUDT14 inhibitor 9

Catalog No.: PC-22201Not For Human Use, Lab Use Only.

NUDT5/NUDT14 inhibitor 9 is a potent dual cell-active NUDT5/NUDT14 inhibitor with SPR KD of 400 nM for purified human NUDT14 protein.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NUDT5/NUDT14 inhibitor 9 is a potent dual cell-active NUDT5/NUDT14 inhibitor with SPR KD of 400 nM for purified human NUDT14 protein.
NUDT5/NUDT14 inhibitor 9 exhibits NUDT5 and NUDT14 cell target engagement with EC50 of 1.08 uM in NUDT5 NanoBRET TE assay.
NUDT5/NUDT14 inhibitor 9 also enabled resolution of the first NUDT14 cocrystal structure, revealing insights into the so-far unresolved N-terminal domain of NUDT14.

Physicochemical Properties

M.Wt	400.49
Formula	C23H24N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-Methylpiperidin-4-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

References

1. Balıkçı E, et al. J Med Chem. 2024 Apr 18. doi: 10.1021/acs.jmedchem.4c00072.

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