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NUDT5/NUDT14 inhibitor 9

Chemical Structure : NUDT5/NUDT14 inhibitor 9

CAS No.: 3056563-44-8

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NUDT5/NUDT14 inhibitor 9 (NUDT5/NUDT14 dual antagonist)

Catalog No.: PC-22201Not For Human Use, Lab Use Only.

NUDT5/NUDT14 inhibitor 9 is a potent dual cell-active NUDT5/NUDT14 inhibitor with SPR KD of 400 nM for purified human NUDT14 protein.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NUDT5/NUDT14 inhibitor 9 is a potent dual cell-active NUDT5/NUDT14 inhibitor with SPR KD of 400 nM for purified human NUDT14 protein.
    NUDT5/NUDT14 inhibitor 9 exhibits NUDT5 and NUDT14 cell target engagement with EC50 of 1.08 uM in NUDT5 NanoBRET TE assay.
    NUDT5/NUDT14 inhibitor 9 also enabled resolution of the first NUDT14 cocrystal structure, revealing insights into the so-far unresolved N-terminal domain of NUDT14.

    Physicochemical Properties

    M.Wt 400.49
    Formula C23H24N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(1-Methylpiperidin-4-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

    References

    1. Balıkçı E, et al. J Med Chem. 2024 Apr 18. doi: 10.1021/acs.jmedchem.4c00072.

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