| Cat. No. |
Product Name |
Information |
| PC-23841 |
SJ44236
BET PROTAC
|
SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4. |
| PC-23795 |
XYD049
GSPT1 degrader
|
XYD049 is a potent, selective CRBN-interacting molecular glue degrader of G1 to S phase transition 1 (GSPT1) with DC50 of 19 nM in 22Rv1 cells. |
| PC-23771 |
RET PROTAC RD-23
RET PROTAC
|
RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells. |
| PC-23735 |
TEAD PROTAC H122
TEAD PROTAC
|
TEAD PROTAC H122 is a potent, selective TEAD PROTAC degrader with DC50 of 3.0 nM in MSTO-211H cells, shows TEAD1 binding affinity with Ki of 0.3 nM, promotes the degradation of TEAD1, TEAD3, and TEAD4 with similar potency. |
| PC-23715 |
PT-129
G3BP1/2 PROTAC
|
PT-129 is the first potent, selective, and efficacious G3BP1/2 PROTAC degrader, induces degradation of G3BP1 and G3BP2 with DC50 of 5 and 10 μM respectively in L929 cells, Dmax=95%. |
| PC-23702 |
CQ627
RIOK2 degrader
|
CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126. |
| PC-23675 |
SMD-3040
SMARCA2 PROTAC
|
SMD-3040 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 12 nM and Dmax = 96% in Hela cells, >500-fold selectivity over SMARC4. |
| PC-23674 |
SMD-3236
SMARCA2 PROTAC
|
SMD-3236 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 0.5 nM and Dmax = 96% in H838 NSCLC cells, >2000-fold selectivity over SMARC4. |
| PC-23665 |
dTAGV-1 hydrochloride
FKBP12 degrader
|
dTAGV-1 hydrochloride is an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12F36V-tagged proteins. |
| PC-23651 |
PARP1 PROTAC 180055
PARP1 PROTAC
|
PARP1 PROTAC 180055 is a potent, PARP1-specific degradation PROTAC compound with DC50 of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. |
| PC-23566 |
YB-3-17
GSPT1 degrader, mTOR inhibitor
|
YB-3-17 is a potent dual-target, dual-mechanism molecule, robustly inhibits mTOR (IC50=0.22 nM) and selectively degrades GSPT1 (DC50=5 nM, U87 cells). |
| PC-23565 |
LZK PROTAC-21A
LZK PROTAC
|
LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM. |
