Chemical Structure : YTHDC1 PROTAC XY-2
CAS No.:
YTHDC1 PROTAC XY-2
Catalog No.: PC-27441Not For Human Use, Lab Use Only.
YTHDC1 PROTAC XY-2 is a selective, efficient PROTAC degrader of N6-Methyladenosine (m6A) reader YTHDC1 with DC50 of 11.42 nM in MOLM13 and 13.59 nM in Kasumi-1 cells respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YTHDC1 PROTAC XY-2 is a selective, efficient PROTAC degrader of N6-Methyladenosine (m6A) reader YTHDC1 with DC50 of 11.42 nM in MOLM13 and 13.59 nM in Kasumi-1 cells respectively.
XY-2 does not cause appreciable changes in the protein levels of YTHDC2 or YTHDF2.
XY-2 induces potent degradation of YTHDC1 at nanomolar concentrations in multiple AML cell lines.
XY-2 promotes celebron- and proteasome-dependent degradation of YTHDC1, without altering YTHDC1 mRNA expression.
XY-2 markedly suppressed proliferation, colony formation, migration and invasion, while inducing robust apoptosis in AML cells.
XY-2 exhibits potent antiproliferative activity in chronic myeloid leukemia K562 cells with IC50 of 125.2 nM.
XY-2 (2.5 or 5 mg/kg, intraperitoneally, once daily) exerts significant antitumor activity in AML xenograft tumor models.
Physicochemical Properties
|
M.Wt
|
658.12
|
|
Formula
|
C32H32ClN9O5
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-((2-chloro-6-(methylamino)-9H-purin-9-yl)methyl)-N-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)benzamide
|
References
1. Zhongpao Xie, et al. Development of the First YTHDC1 Degrader with Improved Antileukemia Activity. JACS Au. 2026 Jun 10;6(7):3778-3789.
Contact Us
sales@probechem.com
