DB-0646 | Multi-target PROTAC | Probechem Biochemicals

Chemical Structure : DB-0646

DB-0646 (DB0646)

Catalog No.: PC-27685Not For Human Use, Lab Use Only.

DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1.

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Biological Activity

DB-0646 is a multi-target PROTAC degrader that degrades over a panel of 125 distinct kinases in various cell lines, induces ubiquitination and degradation of GCK, BUB1 and YES1.

Physicochemical Properties

M.Wt	1041.07
Formula	C52H51F3N14O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[3-[7-[[6-[4-[[1-[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]pentyl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazinyl]-3-pyridinyl]amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

References

1. Donovan KA, et al. Cell. 2020 Dec 10;183(6):1714-1731.e10.

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DB-0646 (DB0646)

Biological Activity

Physicochemical Properties

References

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