| Cat. No. |
Product Name |
Information |
| PC-26238 |
USP39_PROTAC_V1
USP39 PROTAC
|
USP39_PROTAC_V1 is a potent, selective VHL‐based PROTAC degrader of USP39 with KD of 232 nM, DC50 of 1 nM in HeLa cells. |
| PC-26228 |
ITRI-148
AR-NTD PROTAC
|
ITRI-148 is a CRBN-based androgen receptor N-terminal domain (AR-NTD) degrader, degrades AR, AR-V7, and AR mutants with DC50 of 0.05 uM and 0.02 uM for AR and AR-V7in VCaP cells. |
| PC-26219 |
XYD270
BRD9 PROTAC
|
XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively. |
| PC-26139 |
KTX-951
IRAK4 PROTAC
|
KTX-951 is a potent and orally active degrader of IRAK4 and the Ikaros and Aiolos (IMiD) substrates with DC50 of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively, induces proteasomal degradation of these key proteins, leading to the dual inhibition of the NF-κB and IRF4 signaling pathways. |
| PC-26138 |
KTX-582
IRAK4 PROTAC
|
KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model. |
| PC-25951 |
NP1192
NAT10 PROTAC
|
NP1192 is a highly effective PROTAC degrader targeting NAT10, promotes NAT10 KD and inhibits ac4C modification, facilitates NAT10 degradation through the ubiquitin-proteasome system (UPS). |
| PC-25907 |
CPD-2828
IRE1α PROTAC
|
CPD-2828 is the first PROTAC degrader of IRE1α with DC50 of 0.43 uM in HEK293T cell, exhibits CRBN binding IC50 of 0.65 uM. |
| PC-25892 |
CDK6 PROTAC 48a
CDK6 PROTAC
|
CDK6 PROTAC 48a is a potent, selective, KLHDC2-mediated CDK6 PROTAC degrader with DC50 of 37 nM in MOLM-14 cells, selectively degrades CDK6 among 8642 proteins and within the CDK family. |
| PC-25887 |
PLK4 PROTAC SP27
PLK4 PROTAC
|
PLK4 PROTAC SP27 is a potent, selective PLK4 proteolysis targeting chimera (PROTAC) degrader with binding IC50 of 8.4 nM for PLK4, DC50 of 19.5 nM in MCF-7 cells. |
| PC-25872 |
dCDK9-202
CDK9 PROTAC
|
dCDK9-202 is a highly potent, selective PROTAC CDK9 degrader with DC50 of 3.5 nM and CDK9 decline (94.4%) at 25 nM in TC-71 cell line, inhibits cell growth with IC50 of 8.5 nM in TC-71 cells. |
| PC-25871 |
LAG-3 PROTAC-1
LAG-3 PROTAC
|
LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h). |
| PC-25828 |
KG-FP-003
TEAD PROTAC
|
KG-FP-003 is a potent, selective, and durable TEAD PROTAC degrader with biochemicals binding IC50 of 591 nM for CRBN, degrades all TEAD isoforms in NCI-H1299 cells (TEAD1, DC50= 6 nM, TEAD2 DC50= 68 nM, TEAD3 DC50 =12, TEAD4 DC50= 7 nM). |
