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Chemical Structure : MS159
Catalog No.: PC-49208Not For Human Use, Lab Use Only.
MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader of nuclear receptor binding SET domain protein 2 (NSD2), also effectively degrads CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1.
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MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader of nuclear receptor binding SET domain protein 2 (NSD2), also effectively degrads CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1.
MS159 effectively degrades NSD2 in a concentration-, time-, CRBN-, and proteasome-dependent manner.
MS159 is much more effective in suppressing the growth in cancer cells than the parent NSD2 binder UNC6934.
MS159 is bioavailable in mice and is a valuable chemical tool for exploring the roles of NSD2 in health and disease.
| M.Wt | 828.839 | |
| Formula | C43H40N8O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Meng F, et al. J Med Chem. 2022 Jul 27. doi: 10.1021/acs.jmedchem.2c00807.
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