SJ1008030 | JAK2 PROTAC | Probechem Biochemicals

Chemical Structure : SJ1008030

CAS No.: 2863634-96-0

SJ1008030 (SJ 1008030)

Catalog No.: PC-49144Not For Human Use, Lab Use Only.

SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC, potently inhibits MHH-CALL-4 cell growth with IC50 of 5.4 nM.

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5 mg	$598	In stock
10 mg	$898	In stock
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Biological Activity

SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC, potently inhibits MHH-CALL-4 cell growth with IC50 of 5.4 nM.

SJ1008030 potently kills CRLF2r cell lines MHH–CALL-4 and KOPN49, with less potency in MHH–CALL-2 (hypodiploid ALL) and KOPN75 (PAX5-ETV6) cells and the least efficacy in 697 (TCF3-PBX1) and NALM-6 (DUX4-rearranged ALL) cells.

SJ1008030 shows antileukemic efficacy in patient-derived xenograft ALL cells.

Physicochemical Properties

M.Wt	873.950
Formula	C42H43N13O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide

References

1. Yunchao Chang, et al. Blood. 2021 Dec 9;138(23):2313-2326.

SJ1008030 (SJ 1008030)

Biological Activity

Physicochemical Properties

References

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