| Cat. No. |
Product Name |
Information |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-26015 |
CCT400028
Aurora A PROTAC
|
CCT400028 is a second-generation alisertib-derived Aurora A PROTAC with DC50 of 29 nM in MV4-11 leukemia cells, D max=85%, shows excellent selectivity in proteomic and kinase selectivity profiling. |
| PC-25972 |
WWZ-11-098
CDK6 degrader
|
WWZ-11-098 is a potent, selective Palbociclib-based CDK6 degrader with DC50 of 2.6 nM and Dmax of 99.9 % in MOLT4 cells via CRBN-dependent manner, while sparing CDK1, CDK2, CDK4, and CDK9. |
| PC-25951 |
NP1192
NAT10 PROTAC
|
NP1192 is a highly effective PROTAC degrader targeting NAT10, promotes NAT10 KD and inhibits ac4C modification, facilitates NAT10 degradation through the ubiquitin-proteasome system (UPS). |
| PC-25907 |
CPD-2828
IRE1α PROTAC
|
CPD-2828 is the first PROTAC degrader of IRE1α with DC50 of 0.43 uM in HEK293T cell, exhibits CRBN binding IC50 of 0.65 uM. |
| PC-25906 |
G6374
IRE1 PROTAC
|
G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells. |
| PC-25892 |
CDK6 PROTAC 48a
CDK6 PROTAC
|
CDK6 PROTAC 48a is a potent, selective, KLHDC2-mediated CDK6 PROTAC degrader with DC50 of 37 nM in MOLM-14 cells, selectively degrades CDK6 among 8642 proteins and within the CDK family. |
| PC-25887 |
PLK4 PROTAC SP27
PLK4 PROTAC
|
PLK4 PROTAC SP27 is a potent, selective PLK4 proteolysis targeting chimera (PROTAC) degrader with binding IC50 of 8.4 nM for PLK4, DC50 of 19.5 nM in MCF-7 cells. |
| PC-25872 |
dCDK9-202
CDK9 PROTAC
|
dCDK9-202 is a highly potent, selective PROTAC CDK9 degrader with DC50 of 3.5 nM and CDK9 decline (94.4%) at 25 nM in TC-71 cell line, inhibits cell growth with IC50 of 8.5 nM in TC-71 cells. |
| PC-25871 |
LAG-3 PROTAC-1
LAG-3 PROTAC
|
LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h). |
| PC-25869 |
LD-110
LSD1 PROTAC
|
LD-110 is a potent and efficacious PROTAC) degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively. |
