| Cat. No. |
Product Name |
Information |
| PC-25335 |
ABS-752 hydrochloride
GSPT1/NEK7 degrader
|
ABS-752 hydrochloride is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25327 |
JWJ-01-334
ZBTB11 degrader
|
JWJ-01-334 is a negative control compound of JWJ-01-306. |
| PC-25326 |
JWJ-01-368
ZBTB11 degrader
|
JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation. |
| PC-25325 |
JWJ-01-306
ZBTB11 degrader
|
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells. |
| PC-25306 |
LYA914
AR PROTAC
|
LYA914 is a potent, specific PROTAC degrader targeting the conserved DNA binding domain (DBD) of androgen receptor (AR) with DC50 of 0.45 uM and 0.34 uM for AR and AR-V7 in 22Rv1 cells, respectively. |
| PC-25289 |
TBK1 degrader 30
TBK1 degrader
|
TBK1 degrader 30 is a potent, selective TBK1 molecular glue degrader with DC50 of 360.5 and 350.8 nM, and Dmax values of 71.9 and 91.9% in A549 and 293T cells, respectively, induces TBK1 degradation in a dose-, time-, ubiquitin-proteasome system-, and RNF126-dependent manner. |
| PC-25287 |
HaloPROTAC-E
Halo PROTAC
|
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with DC50 of 3-10 nM, significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy. |
| PC-25285 |
NVS-VHL720
CDO1 degrader
|
NVS-VHL720 is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 71 nM, binds with VHL (binary) with SPR KD of 72 nM, induces CDO1 degradation (absDC50 of 8 nM/98% degradation) in HEK293T cells. |
| PC-25284 |
NVS-VHL097
CDO1 degrader
|
NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells. |
| PC-25266 |
MCB-36
KRAS PROTAC
|
MCB-36 a potent, selective pan-KRAS PROTAC degrader, effectively reduces both KRAS and p-ERK protein levels, binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities (Kd =1 pM). |
| PC-25247 |
S3D5
STAT3 PROTAC
|
S3D5 is a potent and selective, BP-1-102-based PROTAC degrader for STAT3 with DC50 of 110 nM in HepG2 cells. |
| PC-25213 |
HPK1 PROTAC 10m
HPK1 PROTAC
|
HPK1 PROTAC 10m is a potent, selective and orally active HPK1 (MAP4K1) PROTAC degrader with DC50 of 5.0 nM, Dmax ≥ 99% in Jurkat cells. |
