| Cat. No. |
Product Name |
Information |
| PC-25306 |
LYA914
AR PROTAC
|
LYA914 is a potent, specific PROTAC degrader targeting the conserved DNA binding domain (DBD) of androgen receptor (AR) with DC50 of 0.45 uM and 0.34 uM for AR and AR-V7 in 22Rv1 cells, respectively. |
| PC-25289 |
TBK1 degrader 30
TBK1 degrader
|
TBK1 degrader 30 is a potent, selective TBK1 molecular glue degrader with DC50 of 360.5 and 350.8 nM, and Dmax values of 71.9 and 91.9% in A549 and 293T cells, respectively, induces TBK1 degradation in a dose-, time-, ubiquitin-proteasome system-, and RNF126-dependent manner. |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
| PC-25287 |
HaloPROTAC-E
Halo PROTAC
|
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with DC50 of 3-10 nM, significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy. |
| PC-25285 |
NVS-VHL720
CDO1 degrader
|
NVS-VHL720 is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 71 nM, binds with VHL (binary) with SPR KD of 72 nM, induces CDO1 degradation (absDC50 of 8 nM/98% degradation) in HEK293T cells. |
| PC-25284 |
NVS-VHL097
CDO1 degrader
|
NVS-VHL097 (VL285 Phenol) is a small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 (CDO1) with CDO1 recruitment (TR-FRET) AC50 of 111 nM, binds with VHL (binary) with SPR KD of 68 nM, induces CDO1 degradation (absDC50 of 349 nM/77% degradation) in HEK293T cells. |
| PC-25266 |
MCB-36
KRAS PROTAC
|
MCB-36 a potent, selective pan-KRAS PROTAC degrader, effectively reduces both KRAS and p-ERK protein levels, binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities (Kd =1 pM). |
| PC-25247 |
S3D5
STAT3 PROTAC
|
S3D5 is a potent and selective, BP-1-102-based PROTAC degrader for STAT3 with DC50 of 110 nM in HepG2 cells. |
| PC-25213 |
HPK1 PROTAC 10m
HPK1 PROTAC
|
HPK1 PROTAC 10m is a potent, selective and orally active HPK1 (MAP4K1) PROTAC degrader with DC50 of 5.0 nM, Dmax ≥ 99% in Jurkat cells. |
| PC-25199 |
TQ-3959
BTK PROTAC
|
TQ-3959 is a potent, selective and orally bioavailable BTK PROTAC degrader with DC50 of 0.4 nM in OCI-Ly10 cell line using an HTRF assay, Dmax=97.7%. |
| PC-25183 |
MGD-22
IKZF1/2/3 degrader
|
MGD-22 is a potent, selective and triple Ikaros proteins IKZF1/2/3 degrader with DC50 of 8.33/9.91/5.74 nM respectively in NCI-H929 cells, all Emax>90%. |
| PC-25160 |
FAK PROTAC FC-11
FAK degrader
|
FAK PROTAC FC-11 is a potent and highly selective FAK PROTAC degrader with DC50 of 0.08 nM in PA-1 cells. |
