| Cat. No. |
Product Name |
Information |
| PC-24021 |
NRX-0492
BTK PROTAC
|
NRX-0492 is a potent, selective cereblon (CRBN)-basesd PROTAC degrader of wild-type and C481 mutant BTK with DC50 of 0.1 nM and 0.2 nM, and DC90 of 0.3 nM and 0.5 nM in TMD8 cells expressing WT or C481S mutant BTK respectively. |
| PC-23960 |
QXG-6442
CK1α PROTAC
|
QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells. |
| PC-23948 |
TD-522
GSPT1 degrader
|
TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells. |
| PC-23947 |
AN5777
GSPT1 degrader
|
AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS. |
| PC-23946 |
LYG-409
GSPT1 degrader
|
LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells. |
| PC-23899 |
AH078
CK1δ /CK1ε PROTAC
|
AH078 is a potent, highly selective PROTAC degrader of CK1δ and CK1ε with DC50 of 200 nM (CK1δ) in HEK293 cells, shows excellent selectivity over the highly related CK1α isoform. |
| PC-23854 |
HDAC6 PROTAC A6
HDAC6 PROTAC
|
HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells. |
| PC-23853 |
FF2049
HDAC1-3 PROTAC
|
FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells. |
| PC-23842 |
SJ995973
BET PROTAC
|
SJ995973 is a highly potent PROTAC degrader of bromodomain and extra-terminal (BET) proteins with DC50 of 0.87 nM in MV4-11 cells (BRD4) and Dmax=99%, inhibits viability of MV4-11 cells with IC50 of 3 pM. |
| PC-23841 |
SJ44236
BET PROTAC
|
SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4. |
| PC-23795 |
XYD049
GSPT1 degrader
|
XYD049 is a potent, selective CRBN-interacting molecular glue degrader of G1 to S phase transition 1 (GSPT1) with DC50 of 19 nM in 22Rv1 cells. |
| PC-23771 |
RET PROTAC RD-23
RET PROTAC
|
RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells. |
