| Cat. No. |
Product Name |
Information |
| PC-26978 |
CCW 28-3
BRD4 PROTAC
|
CCW 28-3 is a bifunctional BRD4 PROTAC degrader linking RNF4 ligand CCW16 to BET bromodomain family inhibitor JQ1, degrades BRD4 in a proteasome- and RNF4-dependent manner. |
| PC-26976 |
R4VPL3-1
RNF4 degrader
|
R4VPL3-1 is a PROTAC-like molecule that induces proteasomal degradation of RNF4, also induces the elimination of VHL in cancer cells. |
| PC-26975 |
RNF4 PROTAC RD12
RNF4 degrader
|
RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage. |
| PC-26928 |
XYD224
BRD9 degrader
|
XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells. |
| PC-26926 |
M9101
Aurora A PROTAC
|
M9101 is a potent, selective and in vivo active Aurora A PROTAC degrader with DC50 value of 2.3 nM in MD-MBA-231 cells. |
| PC-26898 |
PLX-4104
BRD4 degrader
|
PLX-4104 is a potent, selective monovalent DCAF11-acting degrader of BRD4 with DC50 of 2 nM and Dmax of >95% in MV411 cells (24 h), shows antiproliferative activity with IC50 of 4 nM on MV-4-11 cells. |
| PC-26875 |
KTX-545
IRAK4 degrader
|
KTX-545 (KTX545) is a potent, selective IRAK4-targeting degrader with DC50 of 0.9 nM determined in in vitro assays with human monocytes. |
| PC-26832 |
dCDK9-010
CDK9 PROTAC
|
dCDK9‐010 is a highly efficient and selective positive transcription elongation factor b (P-TEFb) complex PROTAC degrader with DC50 of 0.5 uM in NCI‐H226 cells, recruits the MDM2 E3 ligase to induce proteasome-dependent degradation of CDK9 and all cyclin T isoforms. |
| PC-26810 |
NK250
USP7 PROTAC
|
NK250 is a potent, selective, Cullin-Ring-E3 ligase (CRL)-dependent USP7 PROTAC degrader with DC50 of 4 nM in MV4-11 cells (24 h). |
| PC-26773 |
MRT-5702D
G3BP2 molecular glue degrader
|
MRT-5702D is a specific molecular glue degrader targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
| PC-26772 |
MRT-5702
G3BP2 molecular glue degrader
|
MRT-5702 is a specific molecular glue degrader targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
| PC-26727 |
p300 degrader 27
p300 PROTAC degrader
|
p300 degrader 27 is a potent, paralog-selective p300 protein degrader with DC50 of 22.5 nM in U2OS cells, does not affect CBP. |
