QXG-6442 | CK1α PROTAC | Probechem Biochemicals

Chemical Structure : QXG-6442

QXG-6442 (QXG6442)

Catalog No.: PC-23960Not For Human Use, Lab Use Only.

QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells.

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Biological Activity

QXG-6442 is a potent, selective casein kinase 1 alpha (CK1α) degrader with DC50 value of 5.7 nM and Dmax of 90% in in MOLT-4 cells.
QXG-6442 exhibits antiproliferative activity in MOLM-13 cell with IC50 of 41 nM.
QXG-6442, exhibits proteome-wide selectivity for CK1α degradation in MOLT-4 cells at a concentration of 1 μM.

Physicochemical Properties

M.Wt	403.40
Formula	C21H17N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)imidazo[1,2-a]pyridine-2-carboxamide

References

1. Qixiang Geng, et al. J Med Chem. 2025 Jan 28. doi: 10.1021/acs.jmedchem.4c02415.

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QXG-6442 (QXG6442)

Biological Activity

Physicochemical Properties

References

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