Chemical Structure : SJ995973
CAS No.: 2882065-25-8
Catalog No.: PC-23842Not For Human Use, Lab Use Only.
SJ995973 is a highly potent PROTAC degrader of bromodomain and extra-terminal (BET) proteins with DC50 of 0.87 nM in MV4-11 cells (BRD4) and Dmax=99%, inhibits viability of MV4-11 cells with IC50 of 3 pM.
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SJ995973 is a highly potent PROTAC degrader of bromodomain and extra-terminal (BET) proteins with DC50 of 0.87 nM in MV4-11 cells (BRD4) and Dmax=99%, inhibits viability of MV4-11 cells with IC50 of 3 pM.
M.Wt | 730.28 | |
Formula | C37H40ClN7O5S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(5-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)pentyl)acetamide |
1. Min J, et al. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670.
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