| Cat. No. |
Product Name |
Information |
| PC-24558 |
MNK1 PROTAC P11-2
MNK1 PROTAC
|
MNK1 PROTAC P11-2 is a first-in-class, selective MNK1-targeting PROTAC degrader with DC50 of 11.92 nM (MV4-11 cells), Dmax>96%, shows remarkable selectivity for MNK1 over MNK2. |
| PC-24557 |
ERD-1233
ERα degrader
|
ERD-1233 is a potent and orally efficacious PROTAC degrader of estrogen receptor α (ERα) with DC50 of 0.9 nM in MCF-7 cell line, Dmax=100%. |
| PC-24551 |
BD-9136
BRD4 degrader
|
BD-9136 is a potent, highly selective PROTAC degrader of BRD4 with DC50 of 1.2 nM (MV-4-11 cell, 4 h), Dmax=99%, displays >1000-fold selective over BRD2 and BRD3 proteins. |
| PC-24506 |
LZK PROTAC 17
LZK degrader
|
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM. |
| PC-24493 |
YD54
SMARCA2 PROTAC
|
YD54 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 1.2 nM (H322 cell ine), Dmax=99.3%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
| PC-24492 |
YDR1
SMARCA2 PROTAC
|
YDR1 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 6.3 nM (H322 cell ine), Dmax=99.4%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
| PC-24420 |
KMG-1068
GSPT1/2 degrader
|
KMG-1068 is a selective GSPT1/2-targeting molecular glue degrader, binds CRBN through a non-IMiD mechanism, induces proteasomal degradation of GSPT1/2 with DC50 of 126.7 nM for GSPT1 and 42.2 nM for GSPT2 in Jurkat cells. |
| PC-24384 |
MS6178
CFTR DUBTAC
|
MS6178 is a MS5105-based CFTR DUBTAC, significantly increases the CFTR mutant protein level, stabilizes CFTR in a concentration-dependent manner. |
| PC-24383 |
MS7131
USP1-based UTX DUBTAC
|
MS7131 is a first-in-class USP1-recruiting UTX (KDM6A, Ubiquitously transcribed tetratricopeptide repeat X chromosome) deubiquitinase-targeting chimera (DUBTAC), selectively stabilizes the tumor suppressor UTX, but not the oncoprotein JMJD3. |
| PC-24381 |
CDK2 degrader Cpd 5
CDK2 degrader
|
CDK2 degrader Cpd 5 is a potent, selective, in vivo active heterobifunctional CDK2 degrader. |
| PC-24379 |
XZ739
BCL-XL PROTAC
|
XZ739 is a potent, CRBN-dependent PROTAC BCL-XL degrader with DC50 of 2.5 nM (MOLT-4 cells), reduces MOLT-4 cell viability with IC50 of 10.1 nM. |
| PC-24378 |
XZ338
BCL-XL PROTAC
|
XZ338 is a potent, selective BCL-XL PROTAC degrader with binding Ki of 1.71 nM, and DC50 of 0.43 nM in MOLT-4 cells. |
