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ARV-766

Chemical Structure : ARV-766

CAS No.: 2750830-09-0

ARV-766 (Luxdegalutamide, ARV766, ARV 766)

Catalog No.: PC-20665Not For Human Use, Lab Use Only.

ARV-776 (Luxdegalutamide, ARV776) is potent, orally bioavailable PROTAC androgen receptor (AR) degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ARV-776 (Luxdegalutamide, ARV776) is potent, orally bioavailable PROTAC androgen receptor (AR) degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.

Physicochemical Properties

M.Wt 807.97
Formula C45H54FN7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(4-((1-(4-(((1r,3r)-3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-N-((S)-2,6-dioxopiperidin-3-yl)-2-fluorobenzamide

References

1. Daniel P. Petrylak, et al. 2023 ASCO Genitourinary Cancers Symposium

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