Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-ADCs and PROTACs-PROTAC-FHD-609
FHD-609

Chemical Structure : FHD-609

CAS No.: 2676211-64-4

FHD-609 (FHD609, FHD 609)

Catalog No.: PC-20694Not For Human Use, Lab Use Only.

FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex, strong anti-tumor efficacy in a subtype of AML.

Packing Price Stock Quantity
2 mg $198 In stock
5 mg $328 In stock
10 mg $528 In stock
25 mg $898 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex, strong anti-tumor efficacy in a subtype of AML.
FHD-609 is effective at inhibiting the growth of a subset of AML cell lines, induce changes and apoptosis in cell cycle.
FHD-609 exihibits potent anti-tumor efficacy in AML CDX and PDX models.

Physicochemical Properties

M.Wt 829.02
Formula C47H56N8O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-(6-(7-((1-(4-(6-(azetidin-1-yl)-2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Claudia Dominici, et al. Mol Cancer Ther (2023) 22 (12_Supplement): A049.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: