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FHD-609

Chemical Structure : FHD-609

CAS No.: 2676211-64-4

FHD-609 (FHD609, FHD 609)

Catalog No.: PC-20694Not For Human Use, Lab Use Only.

FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex, strong anti-tumor efficacy in a subtype of AML.

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Biological Activity

FHD-609 (FHD609) is a potent and selective heterobifunctional protein degrader (PROTAC) of BRD9, a subunit of non-canonical BAF complex, strong anti-tumor efficacy in a subtype of AML.
FHD-609 is effective at inhibiting the growth of a subset of AML cell lines, induce changes and apoptosis in cell cycle.
FHD-609 exihibits potent anti-tumor efficacy in AML CDX and PDX models.

Physicochemical Properties

M.Wt 829.02
Formula C47H56N8O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-(6-(7-((1-(4-(6-(azetidin-1-yl)-2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Claudia Dominici, et al. Mol Cancer Ther (2023) 22 (12_Supplement): A049.

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