BSJ-04-146 | FAK PROTAC | Probechem Biochemicals

Chemical Structure : BSJ-04-146

CAS No.: 2414478-45-6

BSJ-04-146 (FAK degrader BSJ-04-146)

Catalog No.: PC-20684Not For Human Use, Lab Use Only.

BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM.

Packing	Price	Stock
2 mg	$288	In stock
5 mg	$488	In stock
10 mg	$788	In stock
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Biological Activity

BSJ-04-146 is a potent, selective FAK PROTAC (IC50=26 nM), induces potent and durable FAK degradation in pancreatic and breast cancer cell lines at 10 nM.

Physicochemical Properties

M.Wt	955.05
Formula	C50H57F3N8O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-((4-(1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide

References

1. Eriko Koide, et al. Chembiochem. 2023 Apr 23;e202300141.

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BSJ-04-146 (FAK degrader BSJ-04-146)

Biological Activity

Physicochemical Properties

References

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