| Cat. No. |
Product Name |
Information |
| PC-22214 |
BR-cpd7
FGFR1/2 degrader
|
BR-cpd7 is a potent, selective FGFR1/2-targeting proteolysis targeting chimeric (PROTAC) degrader with DC50 of 10 nM, while sparing FGFR3. |
| PC-22099 |
MS170
AKT PROTAC degrader
|
MS170 (AKT PROTAC degrader) is a potent, selective, cereblon (CRBN)-recruiting AKT PROTAC degrader with DC50 of 32 nM (cellular T-AKT in BT474 cells). |
| PC-22098 |
MS98
AKT PROTAC degrader
|
MS98 (AKT PROTAC degrader) is a potent, selective von Hippel-Lindau (VHL)-recruiting AKT PROTAC degrader with DC50 of 78 nM. |
| PC-22097 |
WH244
BCL-xL/BCL-2 PROTAC
|
WH244 is a potent second-generation dual PROTAC degrader of BCL-2 and BCL-xL with DC50 of 0.6 nM (BCL-xL) and 7.4 nM (BCL-2) in Jurkat cells. |
| PC-22066 |
ZX703
GPX4 degrader
|
ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%. |
| PC-21920 |
CDK9 PROTAC 45
CDK9 PROTAC
|
CDK9 PROTAC 45 is a highly potent, efficacious CDK9 PROTAC degrader, induces cell apoptosis in vitro and inhibits tumor growth in the MDA-MB-231 TNBC model. |
| PC-21882 |
BTX-6654
SOS1 PROTAC degrader
|
BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations. |
| PC-21846 |
IBG1
BRD4 degrader
|
IBG1 is a PROTAC-like, specific degrader of BET bromodomain BRD2 and BRD4 with DC50 of 0.15 nM (BRD4), which comprises the BET family bromodomain inhibitor JQ1 tethered to E7820. |
| PC-21776 |
dEALK1
ALK PROTAC
|
dEALK1 is a small-molecule degrader of EML4-ALK fusion proteins with binding constant (Kd) value of 44 nM for kinase domain of recombinant ALK, overcomes resistance to ALK inhibitor ceritinib. |
| PC-21717 |
Chk1 PROTAC-2
Chk1 PROTAC
|
Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells. |
| PC-21708 |
PROTAC dCE-1
CBP/EP300 degrader
|
PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells. |
| PC-21652 |
DAS-5-oCRBN
c-Src PROTAC
|
DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl. |
