| Cat. No. |
Product Name |
Information |
| PC-23323 |
BET PROTAC SIM1
BRD2 PROTAC
|
BET PROTAC SIM1 is a highly potent, von Hippel-Lindau (VHL)-based BET trivalent PROTAC degrader with preference for BRD2 with DC50 of 1.1 nM, 3.3 nM and 0.7 nM for RD2, BRD3, BRD4 in HEK293 cells, potently inhibits cell viability of MV4;11 AML cell line with IC50 of 1.1 nM (48 h). |
| PC-23305 |
pan-KRAS degrader 4
pan-KRAS PROTAC
|
pan-KRAS degrader 4 is a potent, selective, reversible heterobifunctional pan-KRAS PROTAC degrader with Dmax50 of 17 nM in GP5d cells, efficiently degrades 13 of the 17 most prevalent KRAS mutant alleles and KRASWT with single-digit nanomolar potency. |
| PC-23276 |
DD205-291
HPK1 PROTAC
|
DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM. |
| PC-23233 |
DYR684
DYRK1 PROTAC
|
DYR684 is a potent, and selective PROTAC degrader of DYRK1 with KD of 6.3/16 nM for DYRK1A/DYRK1B, DC50 value of 12.3 nM for DYRK1A in HEK293 cells. |
| PC-23176 |
AK-1690
STAT6 PROTAC
|
AK-1690 is the first, potent and selective PROTAC STAT6 degrader with DC50 of 1 nM in MV4;11 cells, Dmax>95%. |
| PC-23155 |
ZLC491
CDK12/13 PROTAC
|
ZLC491 is a potent, selective, and orally bioavailable CDK12/13 PROTAC degrader with DC50 values of 32 and 28 nM, respectively, in TNBC MDA-MB-231 cells. |
| PC-23149 |
YJ1206
CDK12/13 PROTAC
|
YJ1206 is a selective, orally bioavailable CDK12/13 PROTAC degrader, shows potent degradation effects and inhibits VCaP cell viability (IC50=12.5 nM). |
| PC-23133 |
SMARCA2 PROTAC YD23
SMARCA2 PROTAC
|
SMARCA2 PROTAC YD23 is a potent and selective proteolysis targeting chimera (PROTAC) targeting SMARCA2 with DC50 of 64 nM in H1792 cells and Dmax of 88%. |
| PC-23063 |
BTX-1188
GSPT1 and IKZF1/3 PROTAC
|
Sontigidomide (BTX-1188) is a first-in-class dual degrader of GSPT1 and IKZF1/3 with DC50 of 0.2 nM, 1 nM and 1 nM for GSPT1, IKZF1 and IKZF3 respectively, in DOHH-2 (lymphoma) cells. |
| PC-22963 |
ENL degrader MS41
ENL PROTAC
|
MS41 is a potent and selective, VHL-recruiting ENL PROTAC degrader, induces robust ENL degradation in a variety of human leukemia cell lines with DC50 of 3.50, 2.84, 3.03, and 26.58 nM in MV4;11, SEMK2, Jurkat, and KASUMI1, respectively, Dmax>93%. |
| PC-22955 |
MS8588
cGAS DUBTAC
|
MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22954 |
MS7829
cGAS DUBTAC
|
MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
