| Cat. No. |
Product Name |
Information |
| PC-24021 |
NRX-0492
BTK PROTAC
|
NRX-0492 is a potent, selective cereblon (CRBN)-basesd PROTAC degrader of wild-type and C481 mutant BTK with DC50 of 0.1 nM and 0.2 nM, and DC90 of 0.3 nM and 0.5 nM in TMD8 cells expressing WT or C481S mutant BTK respectively. |
| PC-23963 |
DEG-77
IKZF2/CK1α degrader
|
DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively. |
| PC-23962 |
CC-91633
CK1α degrader
|
CC-91633 (Relzasertideg, BMS-986397, BMS986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α). |
| PC-23961 |
DEG-35
IKZF2/CK1α degrader
|
DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity. |
| PC-23910 |
QZ2135
RET PROTAC
|
QZ2135 is a potent, selective RET PROTAC degrader, effectively degrades RET kinase (DC50=4.7 nM) and its resistant mutants, such as V804M (DC50=17.2 nM) and G810C/R. |
| PC-23898 |
FTO PROTAC QP73
FTO degrader
|
FTO PROTAC QP73 is a first-in-class PROTAC degrader for the RNA demethylase FTO, efficiently induces FTO protein degradation in a dose-, time-, cereblon (CRBN)-, and proteasome-dependent manner in AML cells (DC50=34.9 nM, NB4 cells). |
| PC-23836 |
Gridegalutamide
AR degrader
|
Gridegalutamide (BMS-986409) is an orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity. |
| PC-23772 |
HLB-0532259
Aurora-A PROTAC
|
HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells. |
| PC-23702 |
CQ627
RIOK2 degrader
|
CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126. |
| PC-23675 |
SMD-3040
SMARCA2 PROTAC
|
SMD-3040 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 12 nM and Dmax = 96% in Hela cells, >500-fold selectivity over SMARC4. |
| PC-23674 |
SMD-3236
SMARCA2 PROTAC
|
SMD-3236 is a highly potent, exceptionally selective SMARCA2 PROTAC degrader with DC50 of 0.5 nM and Dmax = 96% in H838 NSCLC cells, >2000-fold selectivity over SMARC4. |
| PC-23444 |
SD-436
STAT3 PROTAC
|
SD-436 is a highly potent and selective STAT3 PROTAC degrader with DC50 of 10 nM and Dmax >95% in SU-DHL-1 lymphoma cell line. |
