| Cat. No. |
Product Name |
Information |
| PC-24664 |
BMS-986449
IKZF2/4 degrader
|
BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors IKZF2 (Helios) and IKZF4 (Eos). |
| PC-24640 |
HDAC7 PROTAC B14
HDAC7 degrader
|
HDAC7 PROTAC B14 is a potent, exceedingly selective HDAC7 PROTAC degrader with DC50 of 25.1 nM in NB4 cells. |
| PC-24632 |
MS9117
LSD1 PROTAC
|
MS9117 is a potent, selective CRBN-based LSD1 PROTAC degrader (DC50<40 nM in THP-1 cells), effectively degrades LSD1 in a concentration-, time-, and proteasome-dependent manner. |
| PC-24575 |
RP03707
KRAS G12D PROTAC
|
RP03707 is a CRBN-involving, highly potent, and selective KRAS G12D PROTAC degrader with DC50 of 0.7 nM in PK-59 cells (Dmax=96%). |
| PC-24555 |
PLX-4545
IKZF2 degrader
|
PLX-4545 (PLX4545) is a potent and selective, orally bioavailable IKZF2 degrader, that depletes IKZF2 and converts suppressive Tregs into effector-like T-cells leading to antitumor immunity. |
| PC-24554 |
PVTX-405
IKZF2 degrader
|
PVTX-405 is a potent, highly selective, rapid and orally efficacious CRBN-dependent glue degrader of IKZF2 with DC50 of 0.7 nM in IKZF2 HiBiT degradation assay in HEK293 cells, Dmax = 91%. |
| PC-24551 |
BD-9136
BRD4 degrader
|
BD-9136 is a potent, highly selective PROTAC degrader of BRD4 with DC50 of 1.2 nM (MV-4-11 cell, 4 h), Dmax=99%, displays >1000-fold selective over BRD2 and BRD3 proteins. |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24380 |
CDK2 degrader Cpd 1
CDK2 degrader
|
CDK2 degrader Cpd 1 is a potent, selective heterobifunctional CDK2 degrader with DC50 of <10 nM and Dmax>90% in TOV21G cells, 1,000-fold selectivity versus CDK1. |
| PC-24242 |
BT-O2C
p300 PROTAC
|
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM). |
| PC-24182 |
KT-253
MDM2 degrader
|
Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer. |
| PC-24133 |
Epaldeudomide
IKZF1/3 molecular glue
|
Epaldeudomide (KPG-818) is a molecular glue modulator of the E3 ubiquitin ligase complex CRL4-CRBN, shows high cereblon (CRBN) binding affinity and potent degradation of Aiolos (IKZF3) and Ikaros (IKZF1), possesses remarkable broad-spectrum immunomodulatory effects, anti-angiogenic, and anti-tumor effects. |
