| Cat. No. |
Product Name |
Information |
| PC-20167 |
TMX-4153
PIP4K2C PROTAC
|
TMX-4153 (TMX4153) is a bivalent PIP4K2C degrader (MOLT4 cells, DC50=24 nM, Dmax=921% at 1 uM) based on TMX-4084, rapidly and selectively degrades endogenous PIP4K2C. |
| PC-20153 |
TMX-4100
PDE6D PROTAC
|
TMX-4100 (TMX4100) is a highly potent PDE6D degrader with DC50 of <200 nM in MOLT4 cells, does not degrade CK1α and IKZF1/IKZF3. |
| PC-20152 |
TMX-4113
PDE6D PROTAC
|
TMX-4113 (TMX4113) is a highly potent PDE6D degrader with DC50 of 40 nM in MM.1S cells, does not degrade CK1α, IKZF1/IKZF3. |
| PC-20151 |
TMX-4116
CK1α PROTAC
|
TMX-4116 (TMX4116) is a highly potent casein kinase 1α (CK1α) degrader with DC50 of <200 nM (CK1α) in MOLT4 cells, does not degrade PDE6D and IKZF1/IKZF3. |
| PC-20149 |
FPFT-2216
KZF1 and CK-1α degrader
|
FPFT-2216 (FPFT2216) is a thalidomide derivative cereblon modulator that shows an inhibitory effect toward IKZF1 protein level, upregulates the production of IL-2 and degrades IKZF1 as well as CK-1α among ubiquitin–proteasomal degradative substrates of IMiDs. |
| PC-20148 |
UNC7700
PRC2 PROTAC
|
UNC7700 (UNC-7700) is a potent EED-targeted PRC2 degrader, contains a unique cis-cyclobutane linker and potently degrades all PRC2 components EED (DC50=111 nM; Dmax=84%), EZH2WT/EZH2Y641N (DC50=275 nM; Dmax=86%) and SUZ12 (Dmax=44%) in DLBCL cells. |
| PC-20147 |
UNC6852
PRC2 PROTAC
|
UNC6852 (UNC-6852) is a chemical degrader of PRC2, contains an EED226-derived ligand and a ligand for VHL, induces proteasomal degradation of PRC2 components, EED (DC50=0.61 uM), EZH2WT/EZH2Y641N (DC50=0.67 uM) and SUZ12. |
| PC-20145 |
NVP-DKY709
IKZF2 degrader
|
NVP-DKY709 (DKY709) is a first-in-class, selective CRBN glue degrader of IKZF2 with DC50 of 4 nM in cellular assays, completely spares degradation of IKZF1/3. |
| PC-20007 |
GMB-475
BCR-ABL1 PROTAC
|
GMB-475 (GMB475) is an allosteric BCR-ABL1 PROTAC with DC50 of 340 nM, degrades the BCR-ABL1 through the ubiquitin-proteasome pathway. |
| PC-49672 |
MS3227
MDM2 PROTAC
|
MS3227 is a proteolysis-targeting chimera (PROTAC) that targets MDM2 by recruiting the E3 ligase VHL, resulting in proteasome-dependent degradation of MDM2. |
| PC-49629 |
AK-2292
STAT5 PROTAC
|
AK-2292 (AK2292) is a first, potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. |
| PC-49622 |
MS147
PRC1 degrader
|
MS147 (MS 147) is the first degrader of PRC1 core components, BMI1 and RING1B, comprises an EED small-molecule binder (EED226, Cat. PC-42321) linked to a ligand of the E3 ligase von Hippel-Lindau (VHL), degrades BMI1/RING1B in an EED-, VHL-, ubiquitination-, and time-dependent manner. |
