| Cat. No. |
Product Name |
Information |
| PC-22356 |
GT-653
KDM5B degrader
|
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner. |
| PC-22345 |
EP300 degrader MC-1
EP300 PROTAC
|
EP300 degrader MC-1 is a specific, bifunctional small molecule EP300 degrader, preferentially degrades EP300 in a proteasome-dependent manner, does not degrade CREBBP. |
| PC-22257 |
LLC0424
NSD2 PROTAC
|
LLC0424 is a potent, selective, in vivo active NSD2 PROTAC degrader with DC50 of 20 nM, Dmax value of 96% in RPMI-8402 cells. |
| PC-22174 |
MS181
PRC1 degrader
|
MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12. |
| PC-22157 |
MS8709
G9a/GLP degrader
|
MS8709 is a potent, selective first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader with DC50 of 274/260 nM in 22Rv1 cells, respectively. |
| PC-22155 |
MPD2
SARS-CoV-2 Mpro PROTAC
|
MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism. |
| PC-22126 |
LD4172
RIPK1 PROTAC
|
LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines. |
| PC-22120 |
ARV-393
BCL6 PROTAC
|
ARV-393 (Zaloblideg, ARV393) is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
| PC-22117 |
BMS-986365
AR degrader
|
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR. |
| PC-22075 |
P1D-34
Pin1 degrader
|
P1D-34 is a first-in-class, potent and covalent PROTAC degrader of Pin1 with DC50 value of 177 nM in MV-4-11 cells, Dmax of 95%. |
| PC-22055 |
AU-24118
mSWI/SNF ATPase PROTAC
|
AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1. |
| PC-22054 |
CBPD-409
CBP/p300 degrader
|
CBPD-409 (CBPD409) is a highly potent, selective, and orally bioavailable CBP/p300 degrader with DC50 0.2-0.4 nM in VCaP, LNCaP, and 22Rv1 AR+ prostate cancer cell lines. |
