| Cat. No. |
Product Name |
Information |
| PC-22590 |
UNC10088
NSD2 degrader
|
UNC10088 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22588 |
UNC8732
NSD2 degrader
|
UNC8732 is a highly potent, second-generation NSD2 degrader with DC50 of 0.06 uM and Dmax of 97%, SPR KD of 76 nM, facilitates FBXO22-mediated degradation of NSD2 in NSD2-mutant ALL. |
| PC-22586 |
dWIZ-2
WIZ degrader
|
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts. |
| PC-22578 |
XZ9002
HDAC3 degrader
|
XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells. |
| PC-22535 |
KI-CDK9d-32
CDK9 degrader
|
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels. |
| PC-22429 |
R1-ICR-5
RIPK1 PROTAC
|
R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis |
| PC-22394 |
MS140
CDK4/6 PROTAC
|
MS140 (XY028-140) is a potent and selective, CRBN-dependent CDK4/6-degrader (PROTAC) with IC50 of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, suppresses Rb/E2F signaling and reduces CDK4 and CDK6 protein levels. |
| PC-22382 |
ZNL-02-096
Wee1 PROTAC
|
ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1. |
| PC-22381 |
SKLB-0124
PRMT6 degrader
|
SKLB-0124 is a selective, first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) with EC50 of 15.4 uM for HCC827 cells. |
| PC-22356 |
GT-653
KDM5B degrader
|
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner. |
| PC-22345 |
EP300 degrader MC-1
EP300 PROTAC
|
EP300 degrader MC-1 is a specific, bifunctional small molecule EP300 degrader, preferentially degrades EP300 in a proteasome-dependent manner, does not degrade CREBBP. |
| PC-22257 |
LLC0424
NSD2 PROTAC
|
LLC0424 is a potent, selective, in vivo active NSD2 PROTAC degrader with DC50 of 20 nM, Dmax value of 96% in RPMI-8402 cells. |
