| Cat. No. |
Product Name |
Information |
| PC-22963 |
ENL degrader MS41
ENL PROTAC
|
MS41 is a potent and selective, VHL-recruiting ENL PROTAC degrader, induces robust ENL degradation in a variety of human leukemia cell lines with DC50 of 3.50, 2.84, 3.03, and 26.58 nM in MV4;11, SEMK2, Jurkat, and KASUMI1, respectively, Dmax>93%. |
| PC-22955 |
MS8588
cGAS DUBTAC
|
MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22954 |
MS7829
cGAS DUBTAC
|
MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22939 |
CW-3308
BRD9 PROTAC
|
CW-3308 is a potent, selective, and orally bioavailable BRD9 PROTAC degrader, effectively reduces the BRD9 protein by 68% at 1 nM (DC50 < 1 nM) and 90% at 10 nM in the G401 rhabdoid tumor cell line. |
| PC-22897 |
HPK1 PROTAC C3
HPK1 PROTAC
|
HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells. |
| PC-22832 |
NCOA4 PROTAC V3
NCOA4 PROTAC
|
NCOA4 PROTAC V3 is a highly efficient VHL-based nuclear receptor coactivator 4 (NCOA4) PROTAC degrader (DC50=3 nM, HeLa cells) and potent ferroptosis inhibitor. |
| PC-22767 |
KT-413
IRAK4 PROTAC
|
Zomiradomide (KT-413) is a potent PROTAC degrader of IRAK4 and IMiD substrates, induces the potent degradation of IRAK4, Ikaros, and Aiolos with DC50 of 6 nM, 1 nM and 1 nM, respectively in OCI-Ly10 cells. |
| PC-22750 |
BSJ-5-63
CDK12/7/9 PROTAC
|
BSJ-5-63 is a potent, triple PROTAC degrader targeting cyclin-dependent kinases (CDKs) CDK12, CDK7, and CDK9, downregulates HRR genes and inhibits AR signaling. |
| PC-22748 |
G9a degrader G9D-4
G9a PROTAC
|
G9D-4 is a first-in-class, potent, selective PRTOAC degrader of protein lysine methyltransferase G9a (EHMT2, KMT1C) with DC50 of 0.1 uM in PANC-1 cells, highly selective over GLP (DC50>10 uM). |
| PC-22688 |
CP134
DYRK2 PROTAC
|
CP134 is a potent, selective PROTAC degrader of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with DC50 of 1.6 uM in MM231 and 3.3 uM in HeLa, respectively. |
| PC-22665 |
JWZ-5-13
CDK7 degrader
|
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner. |
| PC-22612 |
BRD9 PROTAC E5
BRD9 PROTAC
|
BRD9 PROTAC E5 is a highly potent, selective BRD9 PROTAC degrader with DC50 of 16 pM, IC50 of 0.27 nM for antiproliferation in MV4-11 cells. |
