CC-91633 | CK1α PROTAC | Probechem Biochemicals

Chemical Structure : CC-91633

Catalog No.: PC-23962Not For Human Use, Lab Use Only.

CC-91633 (BMS-986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α).

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Biological Activity

CC-91633 (BMS-986397) is a first-in-class, potent and selective CRBN-based molecular glue degrader of casein Kinase 1α (CK1α).

M.Wt	480.83
Formula	C21H16ClF3N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Isoindole-5-carboxamide, N-[(1R)-1-(3-chloro-2-pyridinyl)-2,2,2-trifluoroethyl]-2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-

1. Qixiang Geng, et al. J Med Chem. 2025 Jan 28. doi: 10.1021/acs.jmedchem.4c02415.

2. Patent WO2020243379 A1.

3. Carmen Jimenez, et al. Blood (2024) 144 (Supplement 1): 1395.