| Cat. No. |
Product Name |
Information |
| PC-25827 |
BCL6-760
BCL6 degrader
|
BCL6-760 is a potent a potent, selective, heterobifunctional BCL6 ligand-directed degrader with EC50 of 1.4 nM and 0.8 nM in SU-DHL-4 and OCI-LY-1 cells respectively. |
| PC-25762 |
p53 Y220C DUBTAC A1
p53 Y220C DUBTAC
|
p53 Y220C DUBTAC A1 is a bifunctional small molecule p53 Y220C-specific deubiquitinase-targeting chimera (DUBTAC) recruiting both p53 Y220C and the deubiquitinase OTUB1, effectively reactivates and deubiquitinates mutant p53 Y220C in vitro and in vivo. |
| PC-25737 |
OUN20985
CRBN degrader
|
Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3, induces ubiquitination and proteasomal degradation of CRBN. |
| PC-25736 |
MRT-31619
CRBN degrader
|
MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation. |
| PC-25719 |
BCL6 PROTAC A19
BCL6 PROTAC
|
BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells. |
| PC-25704 |
LD5097
RIPK1 PROTAC
|
LD5097 is a potent, selective RIPK1 PROTAC degrader with DC50 of 0.7 nM in Jurkat cells, Dmax=96% (24h). |
| PC-25693 |
STAT6 PROTAC 1
STAT6 PROTAC
|
STAT6 PROTAC 1 is a potent, selective STAT6 PROTAC degrader with DC50 of <1 nM. |
| PC-25575 |
BRD9 degrader ZZ7
BRD9 degrader
|
BRD9 degrader ZZ7 is a specific, reversible covalent molecular glue degrader that selectively degrades BRD9, covalently engages DCAF16 at Cys178. |
| PC-25541 |
CDK9 degrader PO-8
CDK9 PROTAC
|
CDK9 degrader PO-8 is a potent, selective iCDK9-based PROTAC degrader of CDK9 with DC50 of 0.26 uM in RAW 264.7 cells. |
| PC-25535 |
dHTC3
BRD4 BD1 degrader
|
dHTC3 is a small molecule, FBXO3-dependent and BD1-specific BRD4 degrader, FBXO3 mediates BRD4 degradation by dHTC3. |
| PC-25534 |
(S)-dHTC1
ENL degrader
|
(S)-dHTC1 is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 49 nM for ENL. |
| PC-25533 |
dHTC1
ENL degrader
|
dHTC1 (rac-dHTC1) is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 45 nM for ENL, recruits CRL4CRBN to ENL through an extended interface of protein-protein and protein-ligand contacts, but only after pre-forming the ENL:dHTC1 complex. |
