| Cat. No. |
Product Name |
Information |
| PC-22819 |
KLHDC2-BRD4 PROTAC K2-B4-5e
BRD4 PROTAC
|
KLHDC2-BRD4 PROTAC K2-B4-5e is a hihgly potent KLHDC2-directed PROTAC degrader of BRD4 with DC50 of 6.2 nM against HiBiT-BRD4, Dmax=93%, in PC-3 cells. |
| PC-22803 |
HDAC8 PROTAC Z16
HDAC8 PROTAC
|
HDAC8 PROTAC Z16 (CZH-726) is a potent, selective HDAC8 PROTAC degrader with DC50 of 0.32 nM, Dmax=97% in Jurkat cells. |
| PC-22785 |
XM-U-14
USP7 PROTAC
|
XM-U-14 is a highly potent, selective and efficacious USP7 PROTAC degrader with DC50 of 0.7 nM in RS4;11 cell, Dmax of 93.1%. |
| PC-22771 |
SIAIS630121
NAMPT PROTAC
|
SIAIS630121 is a highly selective NAMPT-targeted PROTAC that promote rapid and potent degradation of iNAMPT and eNAMPT in a cereblon-dependent manner. |
| PC-22770 |
SIAIS630120
NAMPT PROTAC
|
SIAIS630120 is a highly selective NAMPT-targeted PROTAC that promote rapid and potent degradation of iNAMPT and eNAMPT in a cereblon-dependent manner. |
| PC-22769 |
NAMPT PROTAC 632005
NAMPT PROTAC
|
NAMPT PROTAC 632005 is a potent, selective, next-generation PROTAC degrader of nicotinamide phosphoribosyltransferase (NAMPT) with DC50 of < 1 nM and Dmax of 98.2% in Jurkat cells, simultaneously degrades iNAMPT and eNAMPT. |
| PC-22749 |
SMART1
Smurf1 PROTAC degrader
|
SMART1 (Smurf1 PROTAC degrader) is a potent, highly selective degrader of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1) with DC50 of 1-5 nM in HT29 and PANC-1 cells, Dmax of 86%. |
| PC-22720 |
BTK-PROTAC C13
BTK PROTAC
|
BTK-PROTAC C13 is a highly potent, selective and orally bioavailable BTK PROTAC degrader with DC50 of 5.8 nM in Mino cells, Dmax=96%, degrades C481 and T316-mutated BTK proteins |
| PC-22665 |
JWZ-5-13
CDK7 degrader
|
JWZ-5-13 is a bivalent, selective small molecule PROTAC degrader of cyclin-dependent kinase 7 (CDK7), efficiently reduces CDK7 protein levels in a concentration-, time-, VHL- and UPS-dependent manner. |
| PC-22653 |
SJF620
BTK PROTAC
|
SJF620 is a potent, selective, CRBN-recruiting BTK PROTAC degrader with DC50 of 7.9 nM in NAMALWA cells (Dmax 95%). |
| PC-22647 |
SJ11646
LCK PROTAC
|
SJ11646 is a potent, dasatinib-based, cereblon-mediated LCK PROTAC degrader with DC50 of 0.00838 pM in in KOPT-K1 T-ALL cells, cytotoxic IC50 of 0.083pM. |
| PC-22646 |
SJ45566
LCK PROTAC
|
SJ45566 is a potent, selective and orally active dasatinib-based LCK PROTAC degrader with DC50 of 1.21 nM (Dmax 98%) in KOPT-K1 cells. |
